Dogs are the first domesticated animals that have been widely kept as working, hunting, and pet companions. According to recent coarse estimates, there are currently between 700 million and one billion dogs, making them the most abundant predators in the world. We human beings regard dogs as our best friends. Thus, to protect dogs, our friends, from diseases should be listed among the catalogue of biopharmaceutical research.
Antibody phage display, especially monoclonal antibody phage display, is commonly used in disease prevention and treatment. However, when it comes to monoclonal canine antibody, not much information could be offered. Creative Biolabs, fortunately, is an exceptional.
As a recognized leader in the fields of phage display and antibody engineering, Creative Biolabs is specialized in phage display antibody library technology to make monoclonal rabbit, chicken, llama, dog, monkey, mouse and human antibodies. Particularly, they are proud to be the first and the only company to provide monoclonal canine antibody generation services.
Based on their extensive experiences in phage display library construction and screening, scientists in Creative Biolabs have created several immunized canine antibody libraries, from which they have successfully isolated a number of high affinity antibodies using panning techniques. Through this strategy, they can generate custom monoclonal canine antibodies that have the potential to be used in a wide range of biomedical applications, including the treatment of malignant, infectious, inflammatory and autoimmune diseases in dogs, which pave the way for exploration of such applications in canine medicine.
As for antigens that are not suitable for immunization, Creative Biolabs are also pleased to make a custom synthetic canine antibody library for you based on our full understanding of the canine antibody repertoires. They can take the major framework sequence of light chain heavy chain of canine antibody repertoires and then create mutations or variations in all 6 CDR regions (or 2 CDR3 regions). Combined with various mutation strategies, thay can produce canine antibodies against any antigens, including those that are toxic and of no immune response in animals.
Apart from developing monoclonal canine antibodies, Creative Biolabs also established a platform for monoclonal antibody caninization, murinization and humanization services.
About Creative Biolabs
Creative Biolabs is a recognized leader in the fields of phage display and antibody engineering.