Single Domian Antibody Made It Possible for Curing Diseases by Taking Antibody Drugs

The first single domain antibody  being engineered from the heavy-chain antibodies found in camelids has greatly stimulated the development of antibody market.

The Rapid Development of Antibody Drugs

Except brain, the most sophisticated part in a human body is the immune system. In a sense, we are living in a world surrounded by various bacteria. They never cease disturbing us by taking over our living surroundings as their ideal place for breeding. Under this circumstance, antibody is the only one that can take the responsibility of an inner protector. Each antibody model has its own mission. When foreign objects, including microorganism, allergen and toxin, are trying to invade the immune system, antibodies will send out unique chemical signals on receiving which our immune system starts working.

Even with such a complicated self-defense system, we still suffer a lot from disease. While confronting with cancer or respiratory virus infection, the immune system always delays the response. Sometimes it overacts in an asthma attack or when rejection occurs in organ transplantation. It may even mistakenly attack normal cells and leads to rheumatic arthritis and other autoimmune diseases.

For years, pharmaceutical researchers have been trying to create an engineered antibody that can overcome or relieve these immune system diseases. With the efforts of a large group of research team, Creative Biolabs, a US biotech company, successfully engineered single domain antibody  which is also called single domain antibody from the heavy-chain antibodies found in camelids. Creative Biolabs owns its success to three factors, the rapid development of therapeutic antibody, the disturbing problems related to antibody drugs and the unique understanding of camelids concerned biological knowledge by its scientists.

Why It Attracts So Much Attention?

Compared with normal antibodies, this distinct antibody, with only 10% of their molecular mass, is more flexible in terms of chemical property. Thanks to its tiny size and non-hydrophobic property, it performs better in heat as well as acidic and alkali resistances. In the experiment on mice, their being able to remain viable and stable while passing through the mice’s digestive system has further proved the possibility of curing diseases by taking antibody drugs.

Based on all these advantages, Creative Biolabs widened its services to meet more requirements from the market, including the construction of immunized antibody libraries of this specialty and synthetic camelised human single domain antibody  libraries with the usage of llama and camel and DNA synthesis respectively. Bio-panning of single domain antibodies libraries and large scale production of recombinant single domain antibodies are also the fields of its expansion project.

Advertisements

Published by:

creativebiolabs

Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world. Creative Biolabs was founded by scientists who are dedicated to the conquering of cancer. We believe to build up a custom-service-centered business model is important for optimizing the drug development process, leveraging accessible resources, and forming a team of various background to conduct drug discovery in future. Our commitment to this long-term goal motivates us to deliver the highest quality results to our clients with speed.

Categories UncategorizedLeave a comment

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s